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5F-MDMB-2201

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5F-MDMB-2201 (5F-MDMB-PICA) — Certified Synthetic Cannabinoid Reference Standard

Buy 5F-MDMB-2201 power! more formally known as 5F-MDMB-PICA or 5-Fluoro MDMB-PICA — is a highly potent, indole-core synthetic cannabinoid receptor agonist widely recognized as a priority reference material in forensic toxicology and cannabinoid pharmacology. It is structurally defined as methyl (S)-2-[[1-(5-fluoropentyl)-1H-indole-3-carbonyl]amino]-3,3-dimethylbutanoate, featuring a fluorinated pentyl side chain and a tert-leucinate methyl ester amino acid moiety.

First identified in 2014 and among the top five most frequently encountered synthetic cannabinoids in U.S. DEA-seized materials by 2018, 5F-MDMB-2201 remains a high-priority analyte in global drug-monitoring programs due to its extreme potency and evolving analog design. As a certified reference standard, it enables laboratories worldwide to calibrate instruments, validate detection methods, and generate legally defensible data — ensuring analytical confidence when identifying this compound in seized materials, biofluids, and forensic specimens. Buy 5F-MDMB-2201 power online with bitcoin.

Specifications & Chemical Properties

Parameter	Specification
Primary Name	5F-MDMB-2201 / 5F-MDMB-PICA
CAS Number	1971007-88-1
Molecular Formula	C₂₁H₂₉FN₂O₃
Molecular Weight	376.46 g/mol
Chemical Class	Indole-3-carboxamide synthetic cannabinoid
Appearance	White to off-white crystalline powder
Purity (Certified)	≥99% (HPLC-UV / LC-MS verified)
Solubility	Soluble in methanol, DMSO, acetonitrile; limited in water
Storage Stability	Store at -20°C long-term; 2–8°C short-term; ≥24 months stable
Documentation	Full COA, SDS/MSDS, chromatogram, mass spectrum reference
CB₁ Agonist Potency (EC₅₀)	0.45 nM — exceptionally high potency
CB₂ Agonist Potency (EC₅₀)	7.4 nM — CB₁-preferring profile

Potency Note: With a CB₁ EC₅₀ value of 0.45 nM, 5F-MDMB-2201 is approximately 150–200 times more potent than Δ⁹-THC at the CB₁ receptor — a critical factor for both forensic detection sensitivity and laboratory safety protocols.

Educational Context — Pharmacology & Forensic Relevance

5F-MDMB-2201 functions as a high-efficacy full agonist at the CB₁ cannabinoid receptor, with secondary activity at CB₂. It binds orthosterically to the receptor orthostatic site, triggering G-protein signaling and β-arrestin pathways — producing profound cellular responses at nanomole concentrations. The fluorinated alkyl chain enhances metabolic stability and receptor residence time, while the tert-leucinate ester group contributes to the exceptional CB₁ affinity that distinguishes this compound from earlier generations of synthetic cannabinoids. Buy 5F-MDMB-2201 power near me.

Metabolic Profile — Forensic Significance

Upon exposure, 5F-MDMB-2201 undergoes characteristic phase-I biotransformation: ester hydrolysis, oxidative defluorination, pentyl-chain hydroxylation, and N-dealkylation. At least six major metabolites have been structurally characterized. With the carboxylic acid metabolite (resulting from methyl ester hydrolysis) serving as the primary urinary biomarker for retrospective detection. Laboratories require authentic reference standards of both parent compound and metabolites to validate diagnostic assays — a gap our certified materials address directly.

Why Certified Reference Material Matters

In forensic toxicology, identification without a verified reference standard is scientifically indefensible and legally inadmissible. Retention-time matching, mass-spectrum concordance, and calibration-curve quantitation ALL require authenticated, traceable reference material — precisely what we provide. Our 5F-MDMB-2201 batch data is cross-referenced against UNODC, EMCDDA, and DEA spectral libraries, ensuring your method validation aligns with international benchmark data.

Authoritative scheduling and toxicology data: United Nations Office on Drugs and Crime (UNODC) — unodc.org | DEA Diversion Control Division — deadiversion.usdoj.gov | EMCDDA — emcdda.europa.eu

Quality Assurance — Certified Purity & Traceability

When you procure 5F-MDMB-2201 as a reference standard, purity certainty is more important than the number itself. Impurities, positional isomers, or residual synthesis byproducts produce false retention times, distorted peak ratios, and erroneous mass-spectra — invalidating months of analytical work. Our certification protocol includes:

HPLC-UV Purity Confirmation — ≥99% main peak with impurity quantitation
Identity Verification — LC-MS matching reference molecular ion [M+H]⁺ = 377.22
Residual Solvent Testing — meets ICH Q3C international safety limits
Water Content — Karl Fischer titration ≤0.5%
Batch-Specific COA — includes chromatogram, mass-spectrum reference, and expiration
Traceability — chain-of-custody documentation from synthesis to shipping

Every shipment is accompanied by documentation formatted to satisfy ISO 17025, forensic accreditation, and journal publication requirements — so your reference material meets the same rigorous standards as your laboratory.

Regulatory & Compliance Status

5F-MDMB-2201 is internationally controlled — a reflection of its high potency and documented public health risks:

Jurisdiction	Status
United States	Schedule I — permanently scheduled April 7, 2022; DEA registration required
United Nations	Schedule II — placed under international control, effective 2020
European Union	Controlled under NPS framework; authorized research use only
United Kingdom	Class B — Psychoactive Substances Act
Canada	Schedule II — Controlled Drugs and Substances Act
Germany	Anlage II — authorized trade only

Research Eligibility: Purchasing requires institutional affiliation, valid DEA or equivalent national license, and import permits where applicable. Private individuals cannot be supplied. Shipments include full customs-compliant documentation; buyer assumes responsibility for confirming local regulatory status before ordering.

Safe Laboratory Handling & Storage

PPE & Environment: Handle only within a certified fume hood using nitrile/butyl gloves, safety goggles, and a disposable lab coat. Avoid all skin contact — potency exceeds safe handling thresholds at microgram exposure levels.
Storage: -20°C for long-term archive; 2–8°C for working stock. Store in amber-glass or opaque, airtight container with desiccant. Allow container to reach ambient temperature before opening to prevent condensation.
Waste Management: Dispose via institutional hazardous-waste protocols — never introduce to general waste or water systems.

Ordering & Procurement

Qualified researchers may purchase certified 5F-MDMB-2201 reference material through our secure platform:

Packaging: Tamper-evident, heat-sealed primary packaging; crush-resistant outer container.
Quantity Options: Standard reference amounts; institutional bulk pricing available upon request.
Documentation Included: Batch COA, SDS, customs end-use certification, and spectral reference data.
Shipping: Discreet, tracked delivery; international orders require valid import permits + institutional license verification prior to dispatch.

Ready to order? Visit [SHOP] to view current availability, pricing, and quantity tiers. Explore related indole and indazole standards in [ Synthetic Cannabinoids] or our broader catalog at [ Certified Reference Materials]. Institutional accounts: review compliance protocols at [HOME] and contact our technical support team for onboarding.

Frequently Asked Questions

What is 5F-MDMB-2201, and why is it also called 5F-MDMB-PICA?

5F-MDMB-2201 and 5F-MDMB-PICA are the same compound — “2201” is an earlier numerical identifier, while “PICA” (indole-3-carboxamide) is the systematic structural nomenclature. It is a highly potent CB₁ receptor agonist (EC₅₀ = 0.45 nM) commonly encountered in forensic casework, requiring authenticated reference material for unambiguous identification.

What purity and documentation can I expect?

Every batch is HPLC-verified at ≥99% purity, accompanied by a batch-specific Certificate of Analysis including chromatogram, mass-spectrum reference, water-content determination, and expiration date. This documentation supports method validation, accreditation audits, and publication requirements.

Is 5F-MDMB-2201 legal to purchase for research?

It is internationally control — US Schedule I, UN Schedule II, and strict across most jurisdictions. Purchase requires institutional affiliation + DEA or equivalent national license + import permits where applicable. Always verify current status via UNODC and your national competent authority before ordering.

What are the primary research applications?

Three core uses: forensic analytical reference (calibrate LC-MS/GC-MS for seized materials & biofluids), metabolic biomarker development (parent compound + metabolite identification), and pharmacological SAR studies (fluorination & side-chain effects on receptor binding).

How should I store this reference standard?

-20°C long-term; 2–8°C short-term in an airtight, opaque container with desiccant. Protect from moisture and light. Allow to warm to ambient temperature before opening. Properly stored, it maintains certified purity for a minimum of 24 months.

Conclusion — Reference Standards You Can Trust

In forensic toxicology and cannabinoid research, your conclusions are only as reliable as your reference materials. 5F-MDMB-2201 demands particular rigor — its nanomole potency, structural similarity to multiple scheduled analogs, and complex metabolic profile mean cutting corners on purity or documentation produces invalid science and inadmissible court data.

We provide certified 5F-MDMB-2201 reference standard because credible science deserves credible materials. From HPLC certification to metabolite reference data, every batch is engineered to support your method validation, calibration, and publication-ready reporting, so you focus on advancing knowledge, not questioning your standards.

Whether you are building a forensic cannabinoid panel, developing targeted metabolite assays, or exploring indole-carboxamide structure–activity relationships, our commitment to verified purity, complete documentation, and transparent compliance ensures your work stands on solid ground.

DISCLAIMER! This product is sold exclusively for legitimate scientific investigation, forensic analytical method validation, and academic reference work. It is not a pharmaceutical, consumer product, herbal incense, or recreational substance. By purchasing, you confirm institutional affiliation, appropriate licensing, and acceptance of all regulatory controls governing this compound.

This page serves as both a technical educational resource and a commercial product guide — providing qualified researchers with transparent, peer-reviewed-grade information and procurement pathways.